Invasive fungal infections in patients with acute leukemia.

نویسندگان

  • Hui-Hua Hsiao
  • Hui-Jen Tsai
  • Yi-Chang Liu
  • Yi-Ting Tseng
  • Po-Liang Lu
  • Wun-Chi Yang
  • Ta-Chih Liu
  • Sheng-Fung Lin
چکیده

Invasive fungal infections, a serious problem among cancer patients, are increasing in incidence, and can cause morbidity and mortality. Such infections may hinder additional treatment, especially for patients with leukemia. We report here our experiences in the management of invasive fungal infection in patients with acute leukemia. A total of 18 patients were enrolled in the study: 12 had microabscesses of the liver and/or spleen and/or kidneys; four had sinonasal infections; and two had pulmonary infections. Most of the patients (88.9%) received amphotericin B during treatment for fungal infection. Thirteen patients achieved complete response without evidence of fungal infection in follow-up. In the study, there were 11 mortalities, including five patients who died during therapy and six who later died as a result of relapse or refractoriness of the leukemia. We suggest that many patients may have a good response to antifungal therapy, and that fungal infection does not have to preclude additional chemotherapy after proper management. The state of the underlying disease has a strong impact on outcome.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Invasive Aspergillosis in COVID-19: A Review Study and Recommendations for Diagnostic Approaches

Background and purpose: COVID-19 is an emerging viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Bacterial or fungal superinfections of the lung may cause complications in clinical manifestations, treatment, and increase the mortality rate. In this article, we reviewed previous studies on invasive aspergillosis (IA) in viral infections and in adjustment with...

متن کامل

Susceptibility pattern of anti-candida drugs in the pediatric patients with acute leukemia

Background: Pediatric patients on chemotherapy are vulnerable to invasive fungal infection especially Candida spices. Resistance to antifungal agents has increased in Candida spp., especially in non-albicans species. This study aims to assess the susceptibility of Candida spp. strains isolated from children with acute leukemia less than 18 years. Materials and Methods: This prospective cross-s...

متن کامل

Difficult diagnosis of invasive fungal infection predominantly involving the lower gastrointestinal tract in acute lymphoblastic leukaemia

Invasive fungal infections are most commonly seen in immunocompromised patients and usually affect the respiratory system. Gastrointestinal system involvement of mucormycosis and invasive aspergillosis is rarely reported in childhood. Here we describe a 5 year old boy with acute lymphoblastic leukaemia who developed invasive fungal infection particularly affecting the lower gastrointestinal sys...

متن کامل

The Importance of Radiological Findings in Disseminated (Rhinocerebral and Pulmonary) Invasive Fungal İnfection with Childhood Acute Lymphoblastic Leukemia: Case Report

The diagnosis of invasive fungal infection (IFI) is particularly difficult in immunocompromised patients. Clinical and radiological findings supporting the diagnosis of IFI are very important. We presented a case report to emphazise the radiological findings of IFI as a diagnostic tool in an acute lymphoblastic leukemia (ALL) patient with rhinocerebral and pulmonary IFI.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The Kaohsiung journal of medical sciences

دوره 22 5  شماره 

صفحات  -

تاریخ انتشار 2006